Retatrutide (LY3437943)
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Retatrutide is a novel triple hormone receptor agonist (GIP/GLP-1/Glucagon) that provides superior weight loss through multiple complementary mechanisms: GLP-1 receptor activation reduces appetite and food intake, GIP receptor activation enhances insulin secretion and fat metabolism, and glucagon receptor activation increases energy expenditure, promotes hepatic fat oxidation, and reduces liver fat. This synergistic triple-agonism produces the most potent weight loss results seen in clinical trials to date.
| Level | Amount | Frequency | Timing |
|---|---|---|---|
| Beginner | 1 mg | Once weekly | Weeks 1-4 starting dose, subcutaneous injection |
| Standard | 4 mg | Once weekly | Titrate monthly: 1→2→4mg over 12 weeks |
| Advanced | 8-12 mg | Once weekly | Maximum dose, titrate gradually: 1→2→4→8→12mg |
Long-term use under medical supervision, minimum 24-48 weeks for optimal results
Approximately 6 days (allows weekly dosing)
Pre-filled pen expected, or add bacteriostatic water slowly for powder form
Refrigerate at 36-46°F, protect from light
Refrigerate at 36-46°F, use within 28 days
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This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendation. Consult a licensed healthcare professional before using any peptide. BioProtocol does not sell peptides or pharmaceutical products.