Spadin/PE-22-28 Antidepressant Peptide
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Pricing data is updated regularly.
PE-22-28 (Spadin) is a peptide that blocks TREK-1 potassium channels in the brain, mimicking the effect of antidepressants but with rapid onset. It enhances serotonergic and noradrenergic neurotransmission, promotes neurogenesis in the hippocampus, reduces anxiety behaviors, and shows antidepressant effects without traditional SSRI side effects.
| Level | Amount | Frequency | Timing |
|---|---|---|---|
| Beginner | 100-200 mcg | Once daily | Subcutaneous or intranasal, morning |
| Standard | 200-500 mcg | Once daily | Morning, consistent timing |
| Advanced | 500-1000 mcg | Once daily | Under medical supervision |
4-8 weeks, evaluate and adjust
~30-60 minutes
Add bacteriostatic water slowly, swirl gently
Freeze at -4°F
Refrigerate at 36-46°F, use within 14 days
Explore peer-reviewed studies and clinical research on PE-22-28
Peer-reviewed medical research
Active and completed clinical trials
Academic papers and citations
Evidence-based supplement analysis
Research Disclaimer: These links lead to external research databases. Always consult with a qualified healthcare provider before making decisions based on research literature.
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendation. Consult a licensed healthcare professional before using any peptide. BioProtocol does not sell peptides or pharmaceutical products.