Afamelanotide (Melanotan I)
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Melanotan I (Afamelanotide) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that selectively binds to melanocortin 1 receptor (MC1R). Unlike Melanotan II, it has high selectivity for MC1R, stimulating eumelanin production in melanocytes without significant activation of MC3R/MC4R receptors. This leads to increased melanin synthesis and photoprotection without the sexual side effects associated with Melanotan II.
| Level | Amount | Frequency | Timing |
|---|---|---|---|
| Beginner | 0.5 mg | Every other day | Loading phase for 2-3 weeks |
| Standard | 1 mg | Every other day | Loading phase, then maintenance 1-2x per week |
| Advanced | 1-1.5 mg | Daily during loading, then twice weekly | Before UV exposure for enhanced protection |
Loading phase 2-4 weeks, maintenance ongoing as needed
Approximately 30 minutes
Reconstitute with bacteriostatic water, swirl gently
Store at 36-46°F or freeze, protect from light
Refrigerate at 36-46°F, use within 21 days
Explore peer-reviewed studies and clinical research on Melanotan I
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Active and completed clinical trials
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Evidence-based supplement analysis
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