Exenatide (Exendin-4, Byetta)
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Exenatide is a 39-amino acid peptide originally isolated from Gila monster saliva that acts as a GLP-1 receptor agonist. It shares 53% homology with human GLP-1 but has significantly longer duration of action due to resistance to DPP-4 degradation. It stimulates glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon, slows gastric emptying, promotes satiety via hypothalamic signaling, and protects pancreatic beta cells from apoptosis.
| Level | Amount | Frequency | Timing |
|---|---|---|---|
| Beginner | 5 mcg | Twice daily | 60 minutes before morning and evening meals |
| Standard | 10 mcg | Twice daily | 60 minutes before morning and evening meals |
| Advanced | 2 mg extended-release | Once weekly | Any time of day, with or without meals |
Ongoing as prescribed; research protocols vary
2.4 hours (immediate-release); extended-release provides sustained levels
Extended-release: supplied as suspension kit requiring reconstitution per manufacturer instructions
Refrigerate at 36-46°F before first use
Use immediately after reconstitution for ER form; pen can be stored at room temperature for up to 30 days
Explore peer-reviewed studies and clinical research on Exenatide
Peer-reviewed medical research
Active and completed clinical trials
Academic papers and citations
Evidence-based supplement analysis
Research Disclaimer: These links lead to external research databases. Always consult with a qualified healthcare provider before making decisions based on research literature.
This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendation. Consult a licensed healthcare professional before using any peptide. BioProtocol does not sell peptides or pharmaceutical products.