Dulaglutide

Dulaglutide (Trulicity)

Fat Loss

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Pricing data is updated regularly.

Mechanism of Action

Dulaglutide is a long-acting GLP-1 receptor agonist consisting of a GLP-1 analog covalently linked to a modified IgG4 Fc domain via a small peptide linker. This design extends its half-life to approximately 5 days, enabling once-weekly dosing. It activates GLP-1 receptors on pancreatic beta cells to stimulate glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and acts centrally on hypothalamic appetite centers to reduce food intake and promote satiety.

Primary Benefits

  • Once-weekly dosing convenience
  • Significant weight loss (3-5 kg average)
  • Improved glycemic control
  • Reduced cardiovascular events (REWIND trial)
  • Appetite suppression and satiety enhancement
  • Renal protective effects

Common Uses

  • Type 2 diabetes management
  • Weight management in diabetic patients
  • Cardiovascular risk reduction research
  • Long-acting GLP-1 pathway studies
  • Renal protection research

Side Effects

  • Nausea (most common, improves over time)
  • Diarrhea
  • Abdominal pain
  • Decreased appetite
  • Injection site reactions
  • Rare pancreatitis

Contraindications

  • Personal or family history of medullary thyroid carcinoma
  • Multiple endocrine neoplasia syndrome type 2
  • History of pancreatitis
  • Severe gastrointestinal disease
  • Type 1 diabetes

Dosage Protocols

LevelAmountFrequencyTiming
Beginner0.75 mgOnce weeklyAny time of day, with or without meals
Standard1.5 mgOnce weeklySame day each week, any time
Advanced3.0-4.5 mgOnce weeklyHigher doses for weight management goals

Cycle Duration

Ongoing as prescribed; research protocols vary

Half-Life

Approximately 5 days

Reconstitution Instructions

Pre-filled pen device, no reconstitution needed

Storage Requirements

Unreconstituted (Powder):

Refrigerate at 36-46°F, protect from light

Reconstituted:

Pre-filled; can be stored at room temperature ≤86°F for up to 14 days

Research & Literature

Explore peer-reviewed studies and clinical research on Dulaglutide

Research Disclaimer: These links lead to external research databases. Always consult with a qualified healthcare provider before making decisions based on research literature.

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For Research Purposes Only

This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendation. Consult a licensed healthcare professional before using any peptide. BioProtocol does not sell peptides or pharmaceutical products.