ARA-290

ARA-290 (Cibinetide)

Healing

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Mechanism of Action

ARA-290 (Cibinetide) is an 11-amino acid peptide derived from erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a heterodimer of EPO receptor and CD131/β-common receptor. Unlike EPO, it does not stimulate erythropoiesis or increase red blood cell production. It promotes tissue protection, reduces inflammation via NF-κB pathway modulation, stimulates neural regeneration, and activates endogenous repair mechanisms without the thrombotic risks of EPO.

Primary Benefits

  • Neuropathic pain reduction
  • Nerve fiber regeneration in small fiber neuropathy
  • Anti-inflammatory effects without immunosuppression
  • Tissue protection and repair
  • Metabolic improvement in diabetes-related conditions
  • Corneal nerve regeneration

Common Uses

  • Neuropathic pain research
  • Small fiber neuropathy treatment studies
  • Diabetic neuropathy research
  • Sarcoidosis-related neuropathy
  • Tissue repair and regeneration studies

Side Effects

  • Mild injection site reactions
  • Transient headache
  • Mild gastrointestinal discomfort
  • Generally well-tolerated in clinical trials

Contraindications

  • Known hypersensitivity to EPO derivatives
  • Pregnancy and breastfeeding
  • Active thrombotic conditions (precautionary)

Dosage Protocols

LevelAmountFrequencyTiming
Beginner1 mgThree times weeklySubcutaneous injection
Standard2 mgThree times weeklySubcutaneous injection
Advanced4 mgDailySubcutaneous injection, based on clinical protocols

Cycle Duration

4-12 weeks depending on indication

Half-Life

Approximately 10-12 minutes

Reconstitution Instructions

Reconstitute with sterile water or bacteriostatic water, swirl gently

Storage Requirements

Unreconstituted (Powder):

Store at 36-46°F, protect from light

Reconstituted:

Refrigerate, use within 14 days

Research & Literature

Explore peer-reviewed studies and clinical research on ARA-290

Research Disclaimer: These links lead to external research databases. Always consult with a qualified healthcare provider before making decisions based on research literature.

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For Research Purposes Only

This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendation. Consult a licensed healthcare professional before using any peptide. BioProtocol does not sell peptides or pharmaceutical products.