Adipotide

Adipotide (FTPP - Fat-Targeted Proapoptotic Peptide)

Fat Loss

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Mechanism of Action

Adipotide is a chimeric peptide composed of two domains: a targeting sequence (CKGGRAKDC) that binds to prohibitin on the surface of blood vessels supplying white adipose tissue, and a proapoptotic peptide (D(KLAKLAK)2) that disrupts mitochondrial membranes. This dual mechanism selectively destroys the blood supply to fat cells, inducing apoptosis specifically in white adipose tissue while sparing other tissues.

Primary Benefits

  • Targeted fat cell apoptosis
  • Selective destruction of adipose vasculature
  • Significant body fat reduction in studies
  • Improved insulin sensitivity
  • Reduction in BMI and waist circumference

Common Uses

  • Obesity research
  • Targeted fat loss studies
  • Adipose tissue biology research
  • Metabolic syndrome research

Side Effects

  • Kidney stress (renal proximal tubule effects)
  • Mild dehydration
  • Increased urination
  • Injection site reactions
  • Potential transient renal biomarker elevation

Contraindications

  • Kidney disease or impaired renal function
  • Pregnancy and breastfeeding
  • Known hypersensitivity
  • Severe dehydration states

Dosage Protocols

LevelAmountFrequencyTiming
Beginner0.25 mg/kgEvery other daySubcutaneous injection, with adequate hydration
Standard0.5 mg/kgEvery other dayMorning, with increased water intake
Advanced0.5-1 mg/kgDaily for short cyclesMonitor kidney function closely

Cycle Duration

2-4 weeks maximum, with kidney function monitoring

Half-Life

Approximately 45-60 minutes

Reconstitution Instructions

Reconstitute with bacteriostatic water, handle with care

Storage Requirements

Unreconstituted (Powder):

Store at -4°F, protect from light

Reconstituted:

Refrigerate, use within 7 days

Research & Literature

Explore peer-reviewed studies and clinical research on Adipotide

Research Disclaimer: These links lead to external research databases. Always consult with a qualified healthcare provider before making decisions based on research literature.

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For Research Purposes Only

This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment recommendation. Consult a licensed healthcare professional before using any peptide. BioProtocol does not sell peptides or pharmaceutical products.